New Delhi: A new study has found that high levels of per- and polyfluoroalkyl substances (PFAS), also known as "forever chemicals," in the bloodstream can disrupt sleep patterns and potentially lead to various health problems. These chemicals, which are widely used in products like Teflon pans, waterproof clothing, stain-resistant fabrics, and food packaging, have already been linked to cancers of the breast, ovary, skin, and uterus, among other diseases.
The research, led by the University of South California (USC), revealed that elevated levels of four specific types of PFAS in the blood were strongly associated with poor sleep. These chemicals—PFDA, PFHxS, PFOA, and PFOS—are part of a group known as legacy PFAS, which persist in the environment for decades and enter the human body through contact with contaminated consumer goods, food, and water.
Sleep is a critical factor for maintaining good health, with experts recommending 7-8 hours of sleep per night. Chronic sleep deprivation can increase the risk of serious health conditions, including diabetes and Alzheimer's disease. In the study, published in Environmental Advances, researchers collected blood samples and sleep data from 144 participants aged 19 to 24. They found that individuals with higher levels of PFAS in their blood experienced 80 fewer minutes of sleep on average. These participants also reported difficulty falling asleep, staying asleep, and waking up feeling tired.
The study further examined the genetic impact of PFAS on sleep. Out of more than 600 candidate genes, seven genes were identified as being influenced by PFAS exposure and associated with sleep disorders. One of the key genes, HSD11B1, helps produce the hormone cortisol, which regulates the body's sleep-wake cycle. Another gene, cathepsin B, is linked to cognitive function and memory, with disruptions potentially increasing the risk of Alzheimer's disease.
This research adds to the growing body of evidence linking PFAS exposure to a range of health issues, reinforcing concerns about the widespread presence of these chemicals in everyday consumer products and the environment. The findings underscore the importance of addressing PFAS contamination to protect public health, particularly in relation to sleep and its impact on overall well-being.