73-Year-Old Defeats Rare NMDA Encephalitis with 5-Day IVIG Treatment at Jupiter Hospital
Jupiter Hospital recently managed a rare and challenging case of NMDA receptor positive autoimmune encephalitis in a 73-year-old male patient. This condition, typically seen in young women with underlying ovarian teratomas, is exceptionally uncommon in elderly males, making this case a significant example of clinical expertise and patient care.
The patient, who had a history of diabetes mellitus (DM), hypertension (HTN), and carcinoma bladder (post-TURP), presented with severe neurological symptoms, including headache, confusion, drowsiness, and orofacial dyskinetic movements.
Initial investigations, including CT and MRI scans, ruled out an acute infarct or bleed. Further testing confirmed NMDA receptor positive autoimmune encephalitis (both CSF and serum).
The patient underwent an intensive treatment protocol, starting with high-dose steroids (1 gm Solumedrol IV for 3 days) followed by 5 cycles of Intravenous Immunoglobulin (IVIG) therapy.
This multidisciplinary approach, involving specialists from neurology, endocrinology, psychiatry, and critical care, played a crucial role in stabilising the patient’s condition.
“NMDA receptor encephalitis is rare in elderly males and requires high clinical suspicion for early diagnosis. Prompt initiation of steroids and IVIG therapy can be life-saving, as seen in this case.
The patient responded well to treatment and is now on the path to recovery,” said Dr. Yogesh Godge, Consultant Neurologist, Jupiter Hospital, Thane.
Echoing the importance of a comprehensive internal medicine strategy, Dr Javal Bhatt, Consultant, Internal Medicine, Jupiter Hospital, Thane, added, “Managing such a complex case involved carefully balancing the patient’s multiple comorbidities while targeting the underlying autoimmune process.
Timely coordination between departments was key to a positive outcome.”
Following the completion of therapy, the patient showed significant improvement — becoming conscious, responsive, and able to follow commands — marking a successful recovery phase despite the rarity and severity of the condition.
This case highlights Jupiter Hospital’s advanced neuro-care capabilities and its commitment to handling rare and life-threatening conditions through a comprehensive, team-based approach
Khushi Chittoria joined Medical Dialogues in 2025 as a Media and Editorial Intern. She holds a Bachelor degree in Bachelor of Arts degree in Journalism and Mass Communication from IP University and has completed certifications in content writing. She has a strong interest in anchoring, content writing, and editing. At Medical Dialogues, Khushi manages the editorial department, web stories and anchoring.