New Treatment for Chronic Kidney Disease in Dogs: Study

Jerusalem: A team of researchers in Israel has tested a promising new treatment for chronic kidney disease (CKD) in dogs, offering hope for managing the progressive condition that affects many pets, particularly older dogs.

The study, published in the Journal of Veterinary Internal Medicine, focused on the use of paricalcitol, a synthetic form of vitamin D. Conducted by scientists from the Hebrew University of Jerusalem, the research aimed to evaluate the drug’s potential in addressing two common CKD complications: renal secondary hyperparathyroidism (RHPT) and proteinuria (excess protein in the urine), both of which can worsen kidney damage over time.

CKD is a gradual and irreversible disease where the kidneys lose their ability to function properly. It is frequently seen in ageing dogs but can also occur in younger ones. One of the key complications, RHPT, arises when the kidneys are unable to regulate calcium and phosphorus levels, resulting in elevated parathyroid hormone (PTH) levels. This imbalance can weaken bones and damage organs.

The clinical trial involved 13 dogs diagnosed with CKD. Each dog was administered either paricalcitol or a placebo over two 12-week periods. The researchers monitored the dogs’ protein levels, kidney function, and mineral balance throughout the study.

Results showed that dogs receiving the placebo experienced worsening proteinuria, whereas those treated with paricalcitol maintained stable protein levels. This suggests that paricalcitol may play a role in slowing the progression of kidney disease by protecting renal function.

However, a few dogs treated with paricalcitol exhibited mild increases in calcium levels, a known side effect of the drug. Researchers managed this by adjusting the dosage, ensuring safety during the trial period.

Despite the positive outcomes, the researchers emphasized the need for further investigation to confirm the long-term safety and efficacy of paricalcitol in treating canine CKD.

Chronic kidney disease in dogs often presents with symptoms like increased thirst, frequent urination, loss of appetite, vomiting, weight loss, and lethargy. Early diagnosis and proper management, though not curative, can greatly enhance a dog’s quality of life and longevity.